Mouse Cacna1e activation kit by CRISPRa

CAT#: GA200479

Cacna1e CRISPRa kit - CRISPR gene activation of mouse calcium channel, voltage-dependent, R type, alpha 1E subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Cacna1e
• Locus ID: 12290
• Kit Components:

  GA200479G1, Cacna1e gRNA vector 1 in pCas-Guide-CRISPRa

  GA200479G2, Cacna1e gRNA vector 2 in pCas-Guide-CRISPRa

  GA200479G3, Cacna1e gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_009782
• Synonyms: A430040I15; alpha1E; BII; Cach6; Cacnl1a6; Cav2.3; Cchra1
• Summary: This gene encodes an integral membrane protein that belongs to the calcium channel alpha-1 subunits family. Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes. Voltage-dependent calcium channels are multi-subunit complexes, comprised of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The isoform alpha-1E gives rise to R-type calcium currents and belongs to the high-voltage activated group. Calcium channels containing the alpha-1E subunit may be involved in the modulation of neuronal firing patterns, an important component of information processing. [provided by RefSeq, Jul 2008]