Mouse Calca activation kit by CRISPRa

CAT#: GA200495

Calca CRISPRa kit - CRISPR gene activation of mouse calcitonin/calcitonin-related polypeptide, alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Calca
• Locus ID: 12310
• Kit Components:

  GA200495G1, Calca gRNA vector 1 in pCas-Guide-CRISPRa

  GA200495G2, Calca gRNA vector 2 in pCas-Guide-CRISPRa

  GA200495G3, Calca gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001033954, NM_001289444, NM_001305616, NM_007587
• Synonyms: CA; Calc; Calc1; Cgrp; CGRP-1; CGRP1; Ct; Ctn
• Summary: This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide (CGRP) and katacalcin. Alternative splicing of the mRNA results in multiple variants that encode either calcitonin or CGRP preproproteins. Post-translational processing of the calcitonin and CGRP propeptides results in either calcitonin and katacalcin, or CGRP, respectively. Calcitonin and katacalcin modulate calcium levels in the blood stream. CGRP can function as a vasodilator and play a role in the transmission of pain. The human homolog of CGRP was found to have antimicrobial activity. [provided by RefSeq, Mar 2015]