Mouse Casp1 activation kit by CRISPRa

CAT#: GA200533

Casp1 CRISPRa kit - CRISPR gene activation of mouse caspase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Casp1
• Locus ID: 12362
• Kit Components:

  GA200533G1, Casp1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200533G2, Casp1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200533G3, Casp1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_009807
• Synonyms: ICE; Il1bc
• Summary: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. [UniProtKB/Swiss-Prot Function]