Mouse Casp2 activation kit by CRISPRa

CAT#: GA200537

Casp2 CRISPRa kit - CRISPR gene activation of mouse caspase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Casp2
• Locus ID: 12366
• Kit Components:

  GA200537G1, Casp2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200537G2, Casp2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200537G3, Casp2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007610
• Synonyms: CASP-2; ICH-1; NEDD-2; Nedd2
• Summary: This gene encodes the evolutionarily ancient and most conserved member of the cysteine proteases that plays important role in stress-induced apoptosis, DNA repair and tumor suppression. Mice lacking the encoded protein develop normally but display cell type-specific apoptotic defects. Germ cells and oocytes from such mice were found to be resistant to cell death after treatment with chemotherapeutic drugs. [provided by RefSeq, Apr 2015]