Mouse Runx2 activation kit by CRISPRa

CAT#: GA200553

Runx2 CRISPRa kit - CRISPR gene activation of mouse runt related transcription factor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Runx2
• Locus ID: 12393
• Kit Components:

  GA200553G1, Runx2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200553G2, Runx2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200553G3, Runx2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145920, NM_001146038, NM_001271627, NM_001271630, NM_001271631, NM_009820, NR_073392, NR_073425, NM_001271633
• Synonyms: AML3; Cbf; Cbfa-1; Cbfa1; LS3; Osf2; Pebp2a1; PEBP2aA; Pebpa2a
• Summary: This gene encodes a member of the runt domain-containing family of transcription factors. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Sep 2015]