Mouse Cckbr activation kit by CRISPRa

CAT#: GA200576

Cckbr CRISPRa kit - CRISPR gene activation of mouse cholecystokinin B receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Cckbr
• Locus ID: 12426
• Kit Components:

  GA200576G1, Cckbr gRNA vector 1 in pCas-Guide-CRISPRa

  GA200576G2, Cckbr gRNA vector 2 in pCas-Guide-CRISPRa

  GA200576G3, Cckbr gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007627
• Synonyms: CCK-BR; CCK2-R; CCK2R; CCKR-2
• Summary: This gene encodes a multipass transmembrane receptor protein expressed in the central nervous system and gastrointestinal tract. Cholecystokinin and gastrin bind to the encoded protein to stimulate gastric acid secretion and mucosal growth in the gastrointestinal tract, and anxiety, pain sensation and memory in the brain. Mice lacking the encoded protein exhibit an increase in the basal gastric pH and gastrin levels in the bloodstream as well as mild hypocalcemia, secondary hyperparathyroidism and increased bone resorption. [provided by RefSeq, Apr 2015]