Mouse Cd2ap activation kit by CRISPRa

CAT#: GA200610

Cd2ap CRISPRa kit - CRISPR gene activation of mouse CD2-associated protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Cd2ap
• Locus ID: 12488
• Kit Components:

  GA200610G1, Cd2ap gRNA vector 1 in pCas-Guide-CRISPRa

  GA200610G2, Cd2ap gRNA vector 2 in pCas-Guide-CRISPRa

  GA200610G3, Cd2ap gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_009847
• Synonyms: AL024079; C78928; METS-1; Mets1
• Summary: This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. The mouse genome contains at least two pseudogenes located on chromosomes 9 and 17. [provided by RefSeq, Jul 2008]