Mouse Cdc42 activation kit by CRISPRa

CAT#: GA200652

Cdc42 CRISPRa kit - CRISPR gene activation of mouse cell division cycle 42

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Cdc42
• Locus ID: 12540
• Kit Components:

  GA200652G1, Cdc42 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200652G2, Cdc42 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200652G3, Cdc42 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001243769, NM_009861
• Synonyms: AI747189; AU018915
• Summary: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. [UniProtKB/Swiss-Prot Function]