Mouse Cdh1 activation kit by CRISPRa

CAT#: GA200656

Cdh1 CRISPRa kit - CRISPR gene activation of mouse cadherin 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Cdh1
• Locus ID: 12550
• Kit Components:

  GA200656G1, Cdh1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200656G2, Cdh1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200656G3, Cdh1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_009864
• Synonyms: AA960649; ARC-1; E-cad; Ecad; L-CAM; Um; UVO
• Summary: This gene encodes E-cadherin, a calcium-dependent cell adhesion molecule that functions in the establishment and maintenance of epithelial cell morphology during embryongenesis and adulthood. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Targeted mutations disrupting binding of calcium to the encoded protein in mice cause death in utero due to failed blastocyst and trophectoderm formation. This gene is located adjacent to a related cadherin gene on chromosome 8. [provided by RefSeq, Oct 2015]