Mouse Cdkn2c activation kit by CRISPRa

CAT#: GA200681

Cdkn2c CRISPRa kit - CRISPR gene activation of mouse cyclin dependent kinase inhibitor 2C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Cdkn2c
• Locus ID: 12580
• Kit Components:

  GA200681G1, Cdkn2c gRNA vector 1 in pCas-Guide-CRISPRa

  GA200681G2, Cdkn2c gRNA vector 2 in pCas-Guide-CRISPRa

  GA200681G3, Cdkn2c gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001301368, NM_007671
• Synonyms: C77269; INK4c; p18; p18-INK4c; p18-INK6; p18INK4c
• Summary: The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase (cdk) inhibitors, and contains five ankyrin repeats. This protein interacts with both Cdk4 and Cdk6 to inhibit their kinase activities, and prevent their interactions with D-type cyclins, thereby negatively regulating cell division. This gene is differentially expressed in a variety of tissues, and is cell cycle regulated. Deletion of this gene can lead to tumor growth. Maximal expression is observed at the G2/M phase. Alternative splicing and promoter usage results in multiple transript variants. [provided by RefSeq, Aug 2014]