Mouse Chga activation kit by CRISPRa

CAT#: GA200715

Chga CRISPRa kit - CRISPR gene activation of mouse chromogranin A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Chga
• Locus ID: 12652
• Kit Components:

  GA200715G1, Chga gRNA vector 1 in pCas-Guide-CRISPRa

  GA200715G2, Chga gRNA vector 2 in pCas-Guide-CRISPRa

  GA200715G3, Chga gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007693
• Synonyms: cgA; ChrA
• Summary: This gene encodes a member of the granin family of acidic secretory glycoproteins that are expressed in endocrine cells and neurons. The encoded preproprotein undergoes proteolytic processing to generate multiple functions peptides including pancreastatin, catestatin and serpinin. The encoded protein plays important roles in the neuroendocrine system including regulated secretion of peptide hormones and neurotransmitters. Mice lacking the encoded protein exhibit elevated blood pressure which can be rescued by transgenic expression of the human ortholog. [provided by RefSeq, Nov 2015]