Mouse Tpp1 activation kit by CRISPRa

CAT#: GA200760

Tpp1 CRISPRa kit - CRISPR gene activation of mouse tripeptidyl peptidase I

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Tpp1
• Locus ID: 12751
• Kit Components:

  GA200760G1, Tpp1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200760G2, Tpp1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200760G3, Tpp1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_009906
• Synonyms: Cln2; LPIC; TPP-1; TPP-I
• Summary: This gene encodes a lysosomal serine protease that cleaves N-terminal tripeptides from protein substrates. The encoded preproprotein undergoes autocatalytic processing to generate a mature enzyme. Mice lacking the encoded protein exhibit a progressive neurodegeneration and a greatly shortened lifespan. At the cellular level, mice lacking the encoded protein exhibit accumulation of autofluorescent lipopigments. Mutations in the human ortholog of this gene cause classical late-infantile neuronal ceroid lipofuscinosis. [provided by RefSeq, Nov 2015]