Mouse Col1a1 activation kit by CRISPRa

CAT#: GA200829

Col1a1 CRISPRa kit - CRISPR gene activation of mouse collagen, type I, alpha 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Col1a1
• Locus ID: 12842
• Kit Components:

  GA200829G1, Col1a1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200829G2, Col1a1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200829G3, Col1a1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007742
• Synonyms: Col1a-1; Cola-1; Cola1; Mov-13; Mov13
• Summary: This gene encodes the alpha-1 subunit of the fibril-forming type I collagen, the most abundant protein of bone, skin and tendon extracellular matrices. The encoded protein, in association with alpha-2 subunit, forms heterotrimeric type I procollagen that undergoes proteolytic processing during fibril formation. Mice lacking the encoded protein die in utero caused by the rupture of a major blood vessel. Transgenic mice expressing significantly lower levels of this gene exhibit morphological and functional defects in mineralized and non-mineralized connective tissue and, progressive loss of hearing. [provided by RefSeq, Nov 2015]