Mouse Crh activation kit by CRISPRa

CAT#: GA200871

Crh CRISPRa kit - CRISPR gene activation of mouse corticotropin releasing hormone

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Crh
• Locus ID: 12918
• Kit Components:

  GA200871G1, Crh gRNA vector 1 in pCas-Guide-CRISPRa

  GA200871G2, Crh gRNA vector 2 in pCas-Guide-CRISPRa

  GA200871G3, Crh gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_205769
• Synonyms: CRF; Gm1347
• Summary: This gene encodes a member of the corticotropin-releasing factor family and preproprotein that is proteolytically processed to generate a mature protein product. This protein product is a neuropeptide hormone that binds to the corticotropin releasing hormone receptors (CRHR1 and CRHR2) to stimulate the release of adrenocorticotropic hormone from the pituitary gland in response to stress. The encoded protein may also regulate angiogenesis and inflammation. Homozygous knockout mice for this gene exhibit reduced corticosterone levels while the offspring of these mice die perinatally. [provided by RefSeq, Aug 2015]