Mouse Crmp1 activation kit by CRISPRa

CAT#: GA200880

Crmp1 CRISPRa kit - CRISPR gene activation of mouse collapsin response mediator protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Crmp1
• Locus ID: 12933
• Kit Components:

  GA200880G1, Crmp1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200880G2, Crmp1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200880G3, Crmp1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001136058, NM_007765
• Synonyms: CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3
• Summary: This gene encodes a protein that is part of the collapsin response mediator protein family. The family is comprised of five, homologous cytosolic phosphoproteins that are expressed in developing and adult nervous tissue and mediate signaling to transduce responses to extracellular cues. This protein is a Semaphorin 3A signaling molecule that regulates collapse of the growth cone. The growth cone mediates axonal pathfinding in neurons. This protein is reported to represent a new class of microtubule-associated proteins. In humans this protein is reported to inhibit cancer cell invasion. In mouse deficiency of this gene may be associated with impaired spatial memory performance. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]