Mouse Ctsl activation kit by CRISPRa

CAT#: GA200953

Ctsl CRISPRa kit - CRISPR gene activation of mouse cathepsin L

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ctsl
• Locus ID: 13039
• Kit Components:

  GA200953G1, Ctsl gRNA vector 1 in pCas-Guide-CRISPRa

  GA200953G2, Ctsl gRNA vector 2 in pCas-Guide-CRISPRa

  GA200953G3, Ctsl gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_009984
• Synonyms: 1190035F06Rik; CatL; Ctsl1; fs; MEP; nkt
• Summary: This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the activation peptide and the cathepsin L1 heavy and light chains. The mature enzyme appears to be important in embryonic development through its processing of histone H3 and may play a role in disease progression in a model of kidney disease. Homozygous knockout mice for this gene exhibit hair loss, skin thickening, bone and heart defects, and enhanced susceptibility to bacterial infection. A pseudogene of this gene has been identified in the genome. [provided by RefSeq, Aug 2015]