Mouse Cybb activation kit by CRISPRa

CAT#: GA200964

Cybb CRISPRa kit - CRISPR gene activation of mouse cytochrome b-245, beta polypeptide

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Cybb
• Locus ID: 13058
• Kit Components:

  GA200964G1, Cybb gRNA vector 1 in pCas-Guide-CRISPRa

  GA200964G2, Cybb gRNA vector 2 in pCas-Guide-CRISPRa

  GA200964G3, Cybb gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007807
• Synonyms: C88302; Cgd; CGD91-phox; Cyd; gp91-1; gp91phox; Nox2
• Summary: This gene encodes the heavy chain component of a heterodimeric transmembrane ion transporter composed of both a heavy and a light chain. This transporter mediates the transfer of electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to oxygen to generate superoxide. This reaction is important in the innate immune response to pathogens. However, increased activity of the encoded protein also leads to the generation of reactive oxygen species that result in oxidative stress and can cause tissue damage. Conversely, loss of function of the related gene in human causes chronic granulomatous disease. Alternative splicing results in multiple transcript variants, although the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]