Mouse Cd55 activation kit by CRISPRa

CAT#: GA201010

Cd55 CRISPRa kit - CRISPR gene activation of mouse CD55 molecule, decay accelerating factor for complement

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Cd55
• Locus ID: 13136
• Kit Components:

  GA201010G1, Cd55 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201010G2, Cd55 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201010G3, Cd55 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_010016
• Synonyms: Daf; Daf-GPI; Daf1; GPI-DAF
• Summary: This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. The encoded preproprotein undergoes post-translational processing to generate a mature polypeptide anchored to the plasma membrane via a glycosylphosphatidylinositol moiety. Erythrocytes from mice deficient in the encoded protein exhibit impaired regulation of complement activation resulting in enhanced complement deposition. Mice lacking the encoded protein exhibit enhanced susceptibility to experimentally induced myasthenia gravis. This gene is located adjacent to a closely related gene on chromosome 1. [provided by RefSeq, Nov 2015]