Mouse Dcn activation kit by CRISPRa

CAT#: GA201031

Dcn CRISPRa kit - CRISPR gene activation of mouse decorin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Dcn
• Locus ID: 13179
• Kit Components:

  GA201031G1, Dcn gRNA vector 1 in pCas-Guide-CRISPRa

  GA201031G2, Dcn gRNA vector 2 in pCas-Guide-CRISPRa

  GA201031G3, Dcn gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001190451, NM_007833
• Synonyms: DC; DSPG2; PG40; PGII; PGS2; SLRR1B
• Summary: This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate a mature protein product, which is secreted into the extracellular space to regulate collagen fibril assembly. Homozygous knockout mice for this gene exhibit enhanced tumorigenesis in a liver cancer model, and defects in collagen fibrils, leading to weakened skin and tendons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]