Mouse Dhfr activation kit by CRISPRa

CAT#: GA201069

Dhfr CRISPRa kit - CRISPR gene activation of mouse dihydrofolate reductase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Dhfr
• Locus ID: 13361
• Kit Components:

  GA201069G1, Dhfr gRNA vector 1 in pCas-Guide-CRISPRa

  GA201069G2, Dhfr gRNA vector 2 in pCas-Guide-CRISPRa

  GA201069G3, Dhfr gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_010049
• Synonyms: 8430436I03Rik; AA607882; AI662710; AW555094
• Summary: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1. [UniProtKB/Swiss-Prot Function]