Mouse Dmpk activation kit by CRISPRa

CAT#: GA201090

Dmpk CRISPRa kit - CRISPR gene activation of mouse dystrophia myotonica-protein kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Dmpk
• Locus ID: 13400
• Kit Components:

  GA201090G1, Dmpk gRNA vector 1 in pCas-Guide-CRISPRa

  GA201090G2, Dmpk gRNA vector 2 in pCas-Guide-CRISPRa

  GA201090G3, Dmpk gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001190490, NM_001190491, NM_032418, NR_126095
• Synonyms: DM; Dm15; DMK; MDPK; MT-PK
• Summary: The protein encoded by this gene is a serine/threonine protein kinase that contains coiled-coil and C-terminal membrane association domains. In the embryonic mouse, it is found in cardiac and skeletal myocytes where it appears to play a role in myogenesis. In adults, the transcript is localized to several tissues including brain, heart, and skeletal and smooth muscle, and a function in cytoskeletal remodeling has been described. Transcripts with expanded CUG repeats in the 3' untranslated region mediate alternative splicing of several genes and sequester RNA binding proteins and RNA transcripts that contain CAG repeats, resulting in myotonic dystrophy, an autosomal dominant neuromuscular disorder. Alternative splicing results in multiple protein coding and non-coding transcript variants. [provided by RefSeq, Oct 2014]