Mouse Dnmt3b activation kit by CRISPRa

CAT#: GA201110

Dnmt3b CRISPRa kit - CRISPR gene activation of mouse DNA methyltransferase 3B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Dnmt3b
• Locus ID: 13436
• Kit Components:

  GA201110G1, Dnmt3b gRNA vector 1 in pCas-Guide-CRISPRa

  GA201110G2, Dnmt3b gRNA vector 2 in pCas-Guide-CRISPRa

  GA201110G3, Dnmt3b gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001003960, NM_001003961, NM_001003963, NM_001122997, NM_001271744, NM_001271745, NM_001271746, NM_001271747, NM_010068
• Synonyms: MmuIIIB
• Summary: This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene results in severe developmental defects and loss of viability. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. There is a pseudogene for this gene located adjacent to this gene in the same region of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]