Mouse Dsc3 activation kit by CRISPRa

CAT#: GA201136

Dsc3 CRISPRa kit - CRISPR gene activation of mouse desmocollin 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Dsc3
• Locus ID: 13507
• Kit Components:

  GA201136G1, Dsc3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201136G2, Dsc3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201136G3, Dsc3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001291809, NM_007882
• Synonyms: 5430426I24Rik
• Summary: This gene encodes a member of the cadherin family of proteins that mediates adhesion in desmosomes. Together with desmogleins, the encoded protein forms the transmembrane core of desmosomes, a multiprotein complex involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. Mice lacking the encoded protein exhibit a pre-implantation lethal phenotype. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2016]