Mouse Dvl1 activation kit by CRISPRa

CAT#: GA201153

Dvl1 CRISPRa kit - CRISPR gene activation of mouse dishevelled segment polarity protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Dvl1
• Locus ID: 13542
• Kit Components:

  GA201153G1, Dvl1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201153G2, Dvl1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201153G3, Dvl1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001302342, NM_010091, NM_001356381
• Synonyms: Dvl; mKIAA4029
• Summary: The protein encoded by this gene is a member of the Dishevelled family of proteins. These proteins have an N-terminal Dishevelled/Axin domain, a Dishevelled, EGL-10, Plextrin domain, a central PDZ domain, and a C-terminal domain of approximately 200 amino acids. They regulate both canonical and non-canonical Wnt signaling as well as planar cell polarity pathways. Mice deficient for this gene are viable and fertile but display reduced social interaction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]