Mouse Edn1 activation kit by CRISPRa

CAT#: GA201178

Edn1 CRISPRa kit - CRISPR gene activation of mouse endothelin 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Edn1
• Locus ID: 13614
• Kit Components:

  GA201178G1, Edn1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201178G2, Edn1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201178G3, Edn1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_010104
• Synonyms: ET-1; PPET1; preproET
• Summary: This gene encodes a member of the endothelin family of peptides. The encoded preproprotein undergoes proteolytic processing to generate a peptide before secretion by the vascular endothelial cells. The mature peptide has various biological activities such as vasoconstriction, cell proliferation, stimulation of hormone release and modulation of central nervous activity. Mice lacking the encoded protein exhibit neonatal lethality accompanied with numerous craniofacial and cardiovascular defects due to disruption in cranial and cardiac neural crest cell patterning during early embryogenesis. [provided by RefSeq, Feb 2016]