Mouse Ednrb activation kit by CRISPRa

CAT#: GA201182

Ednrb CRISPRa kit - CRISPR gene activation of mouse endothelin receptor type B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ednrb
• Locus ID: 13618
• Kit Components:

  GA201182G1, Ednrb gRNA vector 1 in pCas-Guide-CRISPRa

  GA201182G2, Ednrb gRNA vector 2 in pCas-Guide-CRISPRa

  GA201182G3, Ednrb gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001136061, NM_001276296, NM_007904
• Synonyms: ET-B; ET-BR; ETb; ETR-b; Sox10m1
• Summary: This gene encodes a member of the G-protein coupled receptor family. It encodes a receptor for endothelins, peptides that are involved in vasocontriction. The encoded protein activates a phosphatidylinositol-calcium second messenger system and is required for the development of enteric neurons and melanocytes. Gene disruption causes pigmentation anomalies, deafness, and abnormal dilation of the colon due to defects of neural crest-derived cells. Mutations in this gene are found in the piebald mouse, and mouse models of Hirschsprung's disease and Waardenburg syndrome type 4. Renal collecting duct-specific gene deletion causes sodium retention and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]