Mouse Acsl1 activation kit by CRISPRa

CAT#: GA201349

Acsl1 CRISPRa kit - CRISPR gene activation of mouse acyl-CoA synthetase long-chain family member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Acsl1
• Locus ID: 14081
• Kit Components:

  GA201349G1, Acsl1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201349G2, Acsl1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201349G3, Acsl1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001302163, NM_007981
• Synonyms: Acas; Acas1; Acs; Facl2; FACS; LACS 1; LACS1
• Summary: The protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is expressed in monocytes and macrophages where it appears to have a functionally distinct role in mediating inflammatory and innate immune responses. A pseudogene of this gene is found on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]