Mouse Fgfr3 activation kit by CRISPRa

CAT#: GA201411

Fgfr3 CRISPRa kit - CRISPR gene activation of mouse fibroblast growth factor receptor 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Fgfr3
• Locus ID: 14184
• Kit Components:

  GA201411G1, Fgfr3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201411G2, Fgfr3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201411G3, Fgfr3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001163215, NM_001163216, NM_001163217, NM_001205270, NM_008010, NM_001359036, NM_001359037
• Synonyms: CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3; sam3
• Summary: This gene encodes a member of the fibroblast growth factor receptor family. Members of this family are highly conserved proteins that differ from one another in their ligand affinities and tissue distribution. A representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene may be associated with craniosynostosis and multiple types of skeletal dysplasia. A pseudogene of this gene is located on chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011]