Mouse Fhit activation kit by CRISPRa

CAT#: GA201417

Fhit CRISPRa kit - CRISPR gene activation of mouse fragile histidine triad gene

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Fhit
• Locus ID: 14198
• Kit Components:

  GA201417G1, Fhit gRNA vector 1 in pCas-Guide-CRISPRa

  GA201417G2, Fhit gRNA vector 2 in pCas-Guide-CRISPRa

  GA201417G3, Fhit gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001308285, NM_001308286, NM_010210, NM_001360141
• Synonyms: AW045638; Fra14A2
• Summary: This gene encodes a member of the HIT family of proteins that are characterized by the presence of a histidine triad sequence. The encoded protein is a diadenosine triphosphate hydrolase enzyme that cleaves the P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. This locus is very fragile and has been found to be altered in different types of cancers. Mice lacking the encoded protein display increased susceptibility to spontaneous and induced tumors. Ectopic expression of the encoded protein in such knockout mice inhibits tumor development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]