Mouse Smc2 activation kit by CRISPRa

CAT#: GA201423

Smc2 CRISPRa kit - CRISPR gene activation of mouse structural maintenance of chromosomes 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Smc2
• Locus ID: 14211
• Kit Components:

  GA201423G1, Smc2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201423G2, Smc2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201423G3, Smc2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001301412, NM_008017
• Synonyms: 5730502P04Rik; AI255214; AW545314; CAP-E; CAPE; Fin16; SMC-2; Smc2l1
• Summary: The protein encoded by this gene is a component of both condensin I and condensin II complexes, and forms a heterodimer with structural maintenance of chromosome 4 (Smc4). This heterodimer is the catalytic subunit for both condensin complexes, and is involved in several processes, including chromosome condensation during mitosis and meiosis, cohesin removal during mitosis and meiosis, and single-strand break (SSB) repair. Reduced expression of this gene results in chromosome segregation defects during mitosis and meiosis, with a more severe defect observed in embryonic stem cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]