Mouse Fkbp1a activation kit by CRISPRa

CAT#: GA201426

Fkbp1a CRISPRa kit - CRISPR gene activation of mouse FK506 binding protein 1a

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Fkbp1a
• Locus ID: 14225
• Kit Components:

  GA201426G1, Fkbp1a gRNA vector 1 in pCas-Guide-CRISPRa

  GA201426G2, Fkbp1a gRNA vector 2 in pCas-Guide-CRISPRa

  GA201426G3, Fkbp1a gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001302077, NM_001302078, NM_001302079, NM_001302080, NM_008019, NR_126058, NM_001355077, NM_001355078
• Synonyms: Fkbp; Fkbp1; FKBP12
• Summary: This gene is a member of the immunophilin family. The encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, and is associated with immunoregulation, protein folding, receptor signaling, protein trafficking and T-cell activation. It may modulate the calcium release activity of the ryanodine receptor Ryr1. It also interacts with the type I TGF-beta receptor. Disruption of this gene in mouse causes severe ventricular defects. Pseudogenes of this gene have been defined on chromosomes 4, 10, 14, and 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]