Mouse Gcg activation kit by CRISPRa

CAT#: GA201566

Gcg CRISPRa kit - CRISPR gene activation of mouse glucagon

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Gcg
• Locus ID: 14526
• Kit Components:

  GA201566G1, Gcg gRNA vector 1 in pCas-Guide-CRISPRa

  GA201566G2, Gcg gRNA vector 2 in pCas-Guide-CRISPRa

  GA201566G3, Gcg gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008100
• Synonyms: GLP-1; Glu; PPG
• Summary: This gene encodes glucagon, a pancreatic hormone that counteracts the action of insulin in the bloodstream. The encoded protein is processed to generate glucagon and two other glucagon-like peptides, GLP1 and GLP2. Glucagon stimulates gluconeogenesis, glycogenolysis and lipolysis. GLP1 induces secretion of insulin, suppresses glucagon secretion and inhibits feeding. GLP2 induces intestinal absorption of glucose by stimulating the growth of intestinal cells and preventing apoptosis. [provided by RefSeq, Apr 2015]