Mouse Gfra1 activation kit by CRISPRa

CAT#: GA201595

Gfra1 CRISPRa kit - CRISPR gene activation of mouse glial cell line derived neurotrophic factor family receptor alpha 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Gfra1
• Locus ID: 14585
• Kit Components:

  GA201595G1, Gfra1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201595G2, Gfra1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201595G3, Gfra1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001285457, NM_010279, NR_104342
• Synonyms: AU042498
• Summary: This gene encodes a transmembrane protein that functions as the receptor for glial cell line derived neurotrophic factor (GDNF). The encoded protein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-anchored cell surface coreceptor that forms a complex with the Ret tyrosine kinase in GDNF signaling pathway. Mice lacking the encoded protein exhibit deficits in the kidneys, the enteric nervous system, and spinal motor and sensory neurons similar mice deficient in GDNF or Ret. [provided by RefSeq, Jul 2016]