Mouse Gfra2 activation kit by CRISPRa

CAT#: GA201596

Gfra2 CRISPRa kit - CRISPR gene activation of mouse glial cell line derived neurotrophic factor family receptor alpha 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Gfra2
• Locus ID: 14586
• Kit Components:

  GA201596G1, Gfra2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201596G2, Gfra2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201596G3, Gfra2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001302094, NM_001302095, NM_008115
• Summary: The protein encoded by this gene is part of the receptor complex that transduces glial cell-derived neurotrophic factor and neurturin signals by mediating autophosphorylation and activation of the RET receptor. Mice lacking this protein are viable and fertile but display growth retardation attributed to impaired salivary and pancreatic secretion and innervation deficits in the intestinal tract. In addition, knockout mice display neural defects including a failure to initiate outgrowth of dorsal ganglion root neurons, demonstrating a requirement in neuronal differentiation of these cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]