Mouse Gfra3 activation kit by CRISPRa

CAT#: GA201597

Gfra3 CRISPRa kit - CRISPR gene activation of mouse glial cell line derived neurotrophic factor family receptor alpha 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Gfra3
• Locus ID: 14587
• Kit Components:

  GA201597G1, Gfra3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201597G2, Gfra3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201597G3, Gfra3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_010280
• Synonyms: GFRalpha3; Y15110
• Summary: This gene encodes a cell surface glycoprotein and member of the glial cell line-derived neurotrophic receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein mediates binding of the ligand artemin to the ret receptor tyrosine kinase, and this interaction may regulate thermal pain and axon regeneration. Homozygous knockout mice for this gene exhibit impaired proliferation of cultured neuroblasts and impaired development of the superior cervical ganglion. [provided by RefSeq, Aug 2015]