Mouse Gip activation kit by CRISPRa

CAT#: GA201610

Gip CRISPRa kit - CRISPR gene activation of mouse gastric inhibitory polypeptide

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Gip
• Locus ID: 14607
• Kit Components:

  GA201610G1, Gip gRNA vector 1 in pCas-Guide-CRISPRa

  GA201610G2, Gip gRNA vector 2 in pCas-Guide-CRISPRa

  GA201610G3, Gip gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008119
• Synonyms: MGC129268; MGC129269
• Summary: This gene encodes an incretin hormone that belongs to the glucagon superfamily. The encoded preproprotein undergoes proteolytic processing to generate mature peptides that function as potent stimulators of insulin secretion and inhibit gastric acid secretion. Transgenic mice overexpressing the encoded protein exhibit a significant increase in the expression of markers of bone formation, a decrease in the expression of markers of bone resorption and, an increase in the bone mass. [provided by RefSeq, Nov 2015]