Mouse Glrb activation kit by CRISPRa

CAT#: GA201637

Glrb CRISPRa kit - CRISPR gene activation of mouse glycine receptor, beta subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Glrb
• Locus ID: 14658
• Kit Components:

  GA201637G1, Glrb gRNA vector 1 in pCas-Guide-CRISPRa

  GA201637G2, Glrb gRNA vector 2 in pCas-Guide-CRISPRa

  GA201637G3, Glrb gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001281969, NM_001345955, NM_001345956, NM_001345957, NM_001345958, NM_001345959, NM_001345996, NM_010298
• Synonyms: AI853901; Glyrb; spa; spastic
• Summary: This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. This gene is transcribed throughout the central nervous system of neonatal and adult mice. In humans, mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]