Mouse Spsb2 activation kit by CRISPRa

CAT#: GA201729

Spsb2 CRISPRa kit - CRISPR gene activation of mouse splA/ryanodine receptor domain and SOCS box containing 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Spsb2
• Locus ID: 14794
• Kit Components:

  GA201729G1, Spsb2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201729G2, Spsb2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201729G3, Spsb2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001306050, NM_001306051, NM_001306052, NM_001306053, NM_013539
• Synonyms: AI461677; C9; Grcc9; SSB2
• Summary: This gene encodes a member of the SSB family of proteins that contain a central SPRY (repeats in splA and ryanodine receptors) domain and a C-terminal SOCS (suppressor of cytokine signaling) box. The encoded protein is an adaptor protein in the E3 ubiquitin ligase complex that ubiquitinates inducible nitric oxide synthase and targets it for proteasomal degradation. Mice lacking the encoded protein exhibit lower blood urea nitrogen levels and mild thrombocytopenia due to reduced platelet production. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]