Mouse Gria1 activation kit by CRISPRa

CAT#: GA201731

Gria1 CRISPRa kit - CRISPR gene activation of mouse glutamate receptor, ionotropic, AMPA1 (alpha 1)

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Gria1
• Locus ID: 14799
• Kit Components:

  GA201731G1, Gria1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201731G2, Gria1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201731G3, Gria1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001113325, NM_001252403, NM_008165
• Synonyms: 2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1; GluR-A; gluR-K1; Glur1; GluRA; HIPA1
• Summary: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. [UniProtKB/Swiss-Prot Function]