Mouse Hap1 activation kit by CRISPRa

CAT#: GA201842

Hap1 CRISPRa kit - CRISPR gene activation of mouse huntingtin-associated protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Hap1
• Locus ID: 15114
• Kit Components:

  GA201842G1, Hap1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201842G2, Hap1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201842G3, Hap1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_010404, NM_177981, NM_001359052
• Synonyms: HAP-1
• Summary: The protein encoded by this gene was first identified as a neuronal protein that binds the HD protein huntingtin. The protein also interacts with kinesin light chain, 14-3-3 proteins, and Abelson helper integration site 1 protein. The protein is involved in intracellular trafficking of vesicles and organelles, and lack of the protein results in neuronal death resembling the hypothalamic degeneration that occurs in Huntington's disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]