Mouse Hbegf activation kit by CRISPRa

CAT#: GA201871

Hbegf CRISPRa kit - CRISPR gene activation of mouse heparin-binding EGF-like growth factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Hbegf
• Locus ID: 15200
• Kit Components:

  GA201871G1, Hbegf gRNA vector 1 in pCas-Guide-CRISPRa

  GA201871G2, Hbegf gRNA vector 2 in pCas-Guide-CRISPRa

  GA201871G3, Hbegf gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_010415
• Synonyms: AW047313; Dtr; Dts; Hegfl
• Summary: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. [UniProtKB/Swiss-Prot Function]