Mouse Hgf activation kit by CRISPRa

CAT#: GA201892

Hgf CRISPRa kit - CRISPR gene activation of mouse hepatocyte growth factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Hgf
• Locus ID: 15234
• Kit Components:

  GA201892G1, Hgf gRNA vector 1 in pCas-Guide-CRISPRa

  GA201892G2, Hgf gRNA vector 2 in pCas-Guide-CRISPRa

  GA201892G3, Hgf gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001289458, NM_001289459, NM_001289460, NM_001289461, NM_010427
• Synonyms: C230052L06Rik; HGF/SF; NK1; NK2; SF; SF/HGF
• Summary: This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the hepatocyte growth factor alpha and beta chains, which heterodimerize to form the mature active protein. Although this protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Homozygous knockout mice for this gene exhibit embryonic lethality due to impaired development of the placenta and liver. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]