Mouse Hmox2 activation kit by CRISPRa

CAT#: GA201927

Hmox2 CRISPRa kit - CRISPR gene activation of mouse heme oxygenase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Hmox2
• Locus ID: 15369
• Kit Components:

  GA201927G1, Hmox2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201927G2, Hmox2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201927G3, Hmox2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001136066, NM_010443, NM_001357050
• Synonyms: HO-2; HO2
• Summary: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. [UniProtKB/Swiss-Prot Function]