Mouse Hpse activation kit by CRISPRa

CAT#: GA201976

Hpse CRISPRa kit - CRISPR gene activation of mouse heparanase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Hpse
• Locus ID: 15442
• Kit Components:

  GA201976G1, Hpse gRNA vector 1 in pCas-Guide-CRISPRa

  GA201976G2, Hpse gRNA vector 2 in pCas-Guide-CRISPRa

  GA201976G3, Hpse gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_152803
• Synonyms: Hpa; Hpr1; HSE1
• Summary: This gene encodes an endoglucuronidase enzyme that plays an important role in tumor invasion and metastasis. The encoded preproprotein undergoes proteolytic processing to generate an active heterodimeric enzyme that cleaves the heparan sulfate proteoglycans associated with the cell surface and extracellular matrix. Mice lacking the encoded protein do not show any prominent pathological alterations under normal conditions but fail to develop albuminuria and renal damage in response to drug-induced diabetes. [provided by RefSeq, Aug 2016]