Mouse Igf1 activation kit by CRISPRa

CAT#: GA202086

Igf1 CRISPRa kit - CRISPR gene activation of mouse insulin-like growth factor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Igf1
• Locus ID: 16000
• Kit Components:

  GA202086G1, Igf1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202086G2, Igf1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202086G3, Igf1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001111274, NM_001111275, NM_001111276, NM_001314010, NM_010512, NM_184052
• Synonyms: C730016P09Rik; Igf-1; Igf-I
• Summary: This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. This gene is predominantly expressed in the liver and the encoded protein undergoes proteolytic processing to generate a disulfide-linked mature polypeptide. Transgenic disruption of this gene in mice results in reduced postnatal survival and severe growth retardation. Mice lacking the encoded protein exhibit generalized organ hypoplasia including underdevelopment of the central nervous system and developmental defects in bone, muscle and reproductive systems. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]