Mouse Igf2 activation kit by CRISPRa

CAT#: GA202088

Igf2 CRISPRa kit - CRISPR gene activation of mouse insulin-like growth factor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Igf2
• Locus ID: 16002
• Kit Components:

  GA202088G1, Igf2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202088G2, Igf2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202088G3, Igf2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001122736, NM_001122737, NM_001315488, NM_001315489, NM_010514
• Synonyms: AL033362; Igf-2; Igf-II; M6pr; Mpr; Peg2
• Summary: This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. It is an imprinted gene that is expressed only from the paternal allele. The encoded protein undergoes proteolytic processing to generate a mature peptide. The transgenic overexpression of this gene in mice results in prenatal overgrowth, polyhydramnios, fetal and neonatal lethality, disproportionate organ overgrowth including tongue enlargement, and skeletal abnormalities. Mice lacking the encoded protein exhibit growth deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]