Mouse Igfbp3 activation kit by CRISPRa

CAT#: GA202094

Igfbp3 CRISPRa kit - CRISPR gene activation of mouse insulin-like growth factor binding protein 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Igfbp3
• Locus ID: 16009
• Kit Components:

  GA202094G1, Igfbp3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202094G2, Igfbp3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202094G3, Igfbp3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008343
• Synonyms: AI649005; IGFBP-3; IGgfbp3
• Summary: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. [UniProtKB/Swiss-Prot Function]