Mouse Il12rb1 activation kit by CRISPRa

CAT#: GA202120

Il12rb1 CRISPRa kit - CRISPR gene activation of mouse interleukin 12 receptor, beta 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Il12rb1
• Locus ID: 16161
• Kit Components:

  GA202120G1, Il12rb1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202120G2, Il12rb1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202120G3, Il12rb1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008353
• Synonyms: CD212; IL-12R[b]
• Summary: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. [UniProtKB/Swiss-Prot Function]