Mouse Il7r activation kit by CRISPRa

CAT#: GA202153

Il7r CRISPRa kit - CRISPR gene activation of mouse interleukin 7 receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Il7r
• Locus ID: 16197
• Kit Components:

  GA202153G1, Il7r gRNA vector 1 in pCas-Guide-CRISPRa

  GA202153G2, Il7r gRNA vector 2 in pCas-Guide-CRISPRa

  GA202153G3, Il7r gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008372, NM_001355680
• Synonyms: CD127; IL-7Ralpha
• Summary: Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]