Mouse Irf2 activation kit by CRISPRa

CAT#: GA202181

Irf2 CRISPRa kit - CRISPR gene activation of mouse interferon regulatory factor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Irf2
• Locus ID: 16363
• Kit Components:

  GA202181G1, Irf2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202181G2, Irf2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202181G3, Irf2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008391, NR_152560
• Synonyms: 9830146E22Rik; AI646973; Irf-2
• Summary: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. [UniProtKB/Swiss-Prot Function]